Can Prev Synergy B Complex

Medicinal Ingredients

Each vegetarian capsule contains:

• Choline (bitartrate) 100 mg
• Inositol 100 mg
• L-theanine 100 mg
• Vitamin B5 (calcium-D-pantothenate) 100 mg
• Spirulina (whole, Anthrospira platensis) 60 mg
• Vitamin B1 (thiamine hydrochlorine) 50 mg
• Vitamin B2 (riboflavin-5-phosphate) 50 mg
• Vitamin B3 (niacinamide) 50 mg
• Vitamin B6 (pyridoxal-5-phosphate) 25 mg
• Folate (L-5methyl-tetra-hydrofolate) 500 mcg
• Vitamin B12 (methylcobalamin) 500 mcg
• Biotin 250 mcg

Non-medicinal Ingredients: Hypromellose, microcrystalline cellulose, magnesium stearate.

Suggested dosage: Adults 19 and older: take one capsule two times per day with food or as directed by a health care practitioner.

Vegan, GMO free, contains no binders, fillers, gluten, dairy, soy, wheat, yeast, sugar, artificial colours, flavours, preservatives, or animal products.

What are B vitamins, anyway?

The B-complex family consists of eight essential, water-soluble vitamins, each with distinct roles in human nutrition. They function as coenzymes or participate in processes involved in converting carbohydrates, fats and proteins into usable energy. Certain B vitamins, including folate and B12, also participate in DNA synthesis, red blood cell formation and neurological function. Because most B vitamins are not stored extensively in the body (they are water-soluble), regular dietary intake is important. Vitamin B12 is a notable exception, as the body can maintain substantial stores, primarily in the liver.

CanPrev’s Synergy B is a comprehensive vitamin B complex that provides all eight essential B vitamins in selected bioactive forms, including methylcobalamin (B12), L-5-MTHF folate and pyridoxal-5-phosphate (B6). The formula also delivers 200 mg of L-theanine per recommended daily dose, along with spirulina, a blue-green algae naturally containing phytonutrients, carotenoids and B vitamins.

Developed by CanPrev, Synergy B combines essential B vitamins with complementary nutrients such as choline and inositol. The B vitamins contribute to normal energy metabolism, while L-theanine helps to temporarily promote relaxation. Together, these ingredients offer a thoughtful combination of nutritional support for everyday health and well-being.

Superior folic acid/ folate

Folate, also known as vitamin B9, participates in one-carbon metabolism, a group of biochemical reactions important for DNA synthesis, amino acid metabolism and methylation. Synergy B contains L-5-methyltetrahydrofolate (L-5-MTHF), a form of folate that is also naturally present in human circulation. Unlike synthetic folic acid, which must undergo several metabolic conversion steps, 5-MTHF is already in a biologically active form.

Genetic variations, including certain MTHFR polymorphisms, can influence aspects of folate metabolism. Research has examined the relative bioavailability and utilization of different supplemental folate forms, although individual responses and nutritional requirements can vary.

Further reading: https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/

Superior Vitamin B12: Methylcobalamin

Vitamin B12 is involved in red blood cell formation, neurological function and DNA synthesis. It also works alongside folate in biochemical pathways involved in the metabolism of homocysteine. Synergy B contains methylcobalamin, one of the metabolically active forms of vitamin B12. Other supplemental forms, including cyanocobalamin, can also be converted by the body into active B12 compounds. Research continues to examine differences between B12 forms, including their metabolism and suitability for particular nutritional circumstances. The presence of methylcobalamin does not, by itself, establish superior clinical effectiveness for everyone.

Further reading: https://ods.od.nih.gov/factsheets/Vitaminb12-HealthProfessional/

L-Theanine: The Balance Between Relaxation and Alertness

Green tea (Camellia sinensis) naturally contains both caffeine and L-theanine, two compounds that have attracted scientific interest for their differing, yet potentially complementary, effects on mood and cognitive performance. While caffeine is known for its stimulating properties, L-theanine has been studied for its relationship to relaxation and calmness.

Research suggests that L-theanine may contribute to a state of relaxed alertness, without necessarily producing drowsiness. Studies have also examined the combination of L-theanine and caffeine, with some findings suggesting improvements in attention and cognitive performance.

A randomized, placebo-controlled study by Hidese et al. (2019) investigated the effects of 200 mg of L-theanine daily over four weeks in healthy adults. Researchers observed improvements in several measures relating to perceived stress, sleep quality and certain aspects of cognitive performance, although larger studies are needed to establish the consistency of these effects.

This makes L-theanine an interesting complement to a B-complex formulation. While B vitamins participate in normal energy metabolism and nervous system function, L-theanine has been studied for its potential role in relaxation and mental alertness. CanPrev’s Synergy B brings these ingredients together in a formula designed to support everyday nutritional needs while helping to temporarily promote relaxation.

Further reading:

• Hidese et al. (2019) — Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: https://www.mdpi.com/2072-6643/11/10/2362
• Dietz & Dekker (2017) — Effect of Green Tea Phytochemicals on Mood and Cognition: https://pubmed.ncbi.nlm.nih.gov/28056735/
• Camfield et al. (2014) — Acute Effects of Tea Constituents L-Theanine, Caffeine, and Epigallocatechin Gallate on Cognitive Function and Mood: A Systematic Review and Meta-Analysis: https://pubmed.ncbi.nlm.nih.gov/24946991/

Spirulina, Choline and Inositol

In addition to its B-vitamin content, Synergy B contains three other nutritional ingredients.

• Spirulina (Arthrospira platensis) is a blue-green microalga used in food and nutritional supplements. It contains naturally occurring pigments, proteins and other nutritional compounds.
• Choline is an essential nutrient involved in cell membrane structure, lipid metabolism and the production of acetylcholine, a neurotransmitter.
• Inositol is a naturally occurring carbohydrate compound found in foods and produced by the human body. Its derivatives participate in cell signalling and other physiological processes.

No Added PABA

You may have noticed that PABA (para-aminobenzoic acid) is absent from CanPrev’s Synergy B Complex, although it is sometimes included in other B-complex supplements. Historically referred to as vitamin B10 or vitamin Bx, PABA is not considered an essential vitamin for humans and is not one of the eight recognized B vitamins. PABA was also historically used in sunscreen formulations because of its ability to absorb ultraviolet radiation. However, its topical use has been associated with allergic contact dermatitis and photosensitivity reactions.

Interestingly, PABA also plays a role in bacterial folate synthesis. Sulfonamide antibiotics work by competing with PABA in this biochemical pathway, and laboratory research has demonstrated that additional PABA can counteract their antibacterial activity. However, these findings should not automatically be interpreted as evidence that ordinary dietary exposure to PABA reduces antibiotic effectiveness.

By focusing on the eight essential B vitamins without adding PABA, CanPrev offers a B-complex formulation that does not include this non-essential compound.

Further reading:

• PABA and its role in human nutrition: https://pmc.ncbi.nlm.nih.gov/articles/PMC7023430/
• PABA and allergic contact dermatitis: https://dermnetnz.org/topics/allergy-to-paba
• PABA and sulfonamide antibiotics — biochemical research: https://pmc.ncbi.nlm.nih.gov/articles/PMC2135255/

Safety / Important Information

For adults aged 19 years and older. Consult a healthcare practitioner before use if pregnant or breastfeeding. Keep out of reach of children. Do not use if the safety seal is broken.

According to the current manufacturer instructions, 400 mcg of folate daily is adequate for most women to reduce the risk of neural tube defects. Consult a healthcare practitioner to determine whether additional folate intake would be beneficial.

Follow the directions and precautions on the product’s current label.

60 capsules